Recurrence patterns different for women with triple-negative breast cancer

Filed under: Breast Cancer, Research, Daily news, Cancer Survivors

Triple-negative breast cancer means that the pathology report has shown the cancer to be estrogen receptor negative, progesterone receptor negative, and HER2 negative.

Results published in Clinical Cancer Research found that women with triple negative breast cancer have an increased risk of metastatic disease and death during the first few years after diagnoses, but not after that time period.

A study was conducted among 1,601 breast cancer patients. One hundred and eighty women (11.2%) had triple negative breast cancer.

The results of the study:

• The average age at diagnosis was younger for women with triple-negative breast cancer than for women with other forms of breast cancer.
• Triple-negative breast cancers were more likely than other breast cancers to be node-positive.
• Even after accounting for factors such as tumor size and lymph node status, women with triple-negative breast cancer were more likely than other women to experience a distant cancer recurrence or death. This increased risk, however, was only seen during the first five years after diagnosis.
• The pattern of distant cancer recurrence was different among women with triple-negative breast cancer than among women with other forms of breast cancer. Among women with triple-negative breast cancer, risk of distant recurrence peaked at roughly three years after diagnosis and then declined rapidly. Among women with other forms of breast cancer, risk of recurrence was fairly constant over time.

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[Source: The Cancer Blog]