Mutation in LKB1 helps lung cancers develop into aggressive cases

Filed under: Lung Cancer

Flaws in a key gene LKB1 helps lung cancers develop swiftly into metastasising tumors according to a study in mice led by by Kwok-Kin Wong of the Dana Farber Cancer Institute. LKB1 has previously been identified as helping the body to suppress cancer. In mice, the researchers found that mutations of this gene result in more aggressive tumors.

The researchers examined human non-small-cell lung tissues also and discovered that of the 144 samples, 34% of the lung adenocarcinomas and 19% of the squamous cell carcinomas contained abnormal versions of LKB1.

According to the authors, analyzing this gene could help predict how cancer will develop in a patient.

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[Source: The Cancer Blog]